what is metabolic syndrome ?
metabolic syndrome encompasses three or more than three disorders related to metabolism. It is a term which refers to a cluster of conditions, including various interrelated cardio - metabolic risk factors that promote development of atherosclerotic cardiovascular diseases and type 2 diabetes. The cluster of conditions include increase blood pressure, high blood sugar, excess body fat around waist and abnormal cholesterol levels. Although any of these conditions increase risk of serious disease, presence of one of these conditions does not indicate metabolic syndrome. The term metabolic syndrome is necessarily used in conditions where you have most of the above conditions at once resulting in serious complication.
According to a study in Indians, females were three times more likely to have metabolic syndrome when compared to males, Individuals with hypercholesterolemia were almost two and half times as likely to be at risk of metabolic syndrome as those with normal levels.some important cause for metabolic syndrome are :::
obese people having large waistline and greater body mass index.These people have five times higher risk of metabolic syndrome. obesity as an epidemic is considered as primarily responsible for prevalence of metabolic syndrome.
People with sedentary lifestyle are more prone to insulin resistance, Diabetes and hence metabolic syndrome.
people in south Asian countries are seen to be at higher risk of metabolic syndrome as indicated by it's high prevalence in those region.
people under medications such as some of the anti - inflammatory drugs,Anti - retroviral drugs,anti - allergic,anti - depressants and anti - psychotic agents increase the risk of obesity, in turn elevating the risk of metabolic syndrome.
Aging increases the risk factors associated with metabolic syndrome.
It has been a topic of debate, whether people consuming less anti - oxidants and more of trans - fats are at greater risk than those consuming more of sour fruits and balanced diet.
other conditions :::
people with risk factors related to heart diseases which are responsible for long or short term cardiac risk like high LDL,low HDL etc,are inclined to getting metabolic syndrome. People who have been diagnosed with other conditions like blood pressure, cardiovascular diseases, polycystic ovarian syndrome etc are also prone to metabolic syndrome.
obesity and body fat distribution :
losing weight is primary treatment for metabolic syndrome. It includes plans of healthy living like regular exercise for 30 minutes, Walking healthy eating and quitting smoking would help to check metabolic syndrome. Losing weight would in turn lower the levels of cholesterol and triglycerides, increase the levels of HDL and also lowers blood pressure values all these implications would reduce the risk of cardiovascular diseases.
Targeting insulin resistance :::
Targeting insulin resistance along with measures to control obesity will have a synergistic effect as treatment therapy. Metformin and insulin sensitizers such as thiazolidinediones are used to reduce insulin resistance. Among these, metformin has shown to reduced risk of CHD in obese diabetic people.
Targeting therapy involving treatment for individual risk :::
Risk factors like atherogenic dyslipidemia ,blood pressure, prothrombotic state,pro - inflammatory state,and hyperglycemia (diabetes) can be targeted individually for effective treatment of metabolic syndrome.
Being a lifestyle disease, right diet,exercises along with regular health monitoring of blood cholesterol levels would help in prevention as well as diagnosis of metabolic syndrome.